*** UPDATE ***
I-75 northbound has now REOPENED at the Birch Run exit.
*** END UPDATE ***
I-75 northbound at the Birch Run exit is closed due to multiple accidents.
The Michigan Department of Transportation says to approach with caution and seek an alternate route.
The expressway is closed up to mile marker 42.
Stay with NBC25 for more information about this closure as it comes in to our newsroom.