Officials are asking people to stay off of M-15 between Richville and Vassar.
There have been multiple crashes, including one involving a police car.
The Michigan Department of Transportation (MDOT) has said that M-15 between Sanilac Road and Division Street is closed. This is all lanes.
The winter weather has made for treacherous road conditions. Bay County has asked people to stay off the roads. Saginaw County has asked residents to have extreme caution when out driving.