The victory gives the Spartans (15-2, 4-0 Big Ten) their longest win streak since the 1998-99 season, when they won 22 in a row before losing to Duke in the national championship game.
The Hawkeyes (10-8, 2-3) have been routed in two straight games ?? they also lost to Ohio State, by 29 points ?? after beating Wisconsin and Minnesota on the road.
Reserve Aaron White scored 15 points and Devyn Marble had 12 for Iowa.
Michigan State went on a 16-0 run late in the first half and had a 14-0 spurt midway through the second. During the second burst, Iowa coach Fran McCaffery was called for a technical for berating an official. McCaffery then directed his anger toward his players, slamming a chair in their timeout huddle and screaming in their faces.
The Spartans had a chance for their second-largest margin of victory over a Big Ten team, trailing only its 51-point win over Michigan during their 2000 championship season, but their reserves couldn't maintain a 40-plus lead.
Keith Appling had 15 points and a career-high nine assists, helping the Spartans pile up more assists (25) than Iowa had baskets on a 23-of-63 shooting night.
The Spartans took control soon after the tip, going on an 8-0 run to take a 10-2 lead, and turned the game into a rout with 16 straight points to take a 46-22 lead.
They made nearly 60 percent of their shots in the first half and nine players made at least a shot. Brandon Wood had 10 points of his 12 points in the first half.
Michigan State didn't give the Hawkeyes any comeback hopes in the second half after they pulled within 18 points. The Spartans' second big run of the game gave them a 73-41 cushion and they cruised from there.
Reserves Derrick Nix and Travis Trice scored 10 points apiece for the Spartans, who made 62 percent of their shots and held Iowa to 37-percent shooting.
Iowa's Matt Gatens scored 11 points and Melsahn Basabe had 10.
Michigan State, which improved to 11-0 at home this season, hasn't lost since opening the season with setbacks to North Carolina and Duke.
The Spartans have won 17 straight at the Breslin Center dating to 1993 against the Hawkeyes.
Iowa had won its first two Big Ten road games for the first time since the 2000-01.
Post game Izzo said he couldn't be happier for his team or for their teamwork.
"The 15 assists on19 baskets in the first half is probably the most impressive thing to me," Izzo said. "The unselfishness is second to none."
"You don't have many nights like that one when you shoot the ball like we did," MSU Senior Forward Draymond Green said. "But you know, guys have been coming in and doing some extra shooting. It just shows the more work you put in to it, the more you get out of it."