Nik Stauskas scored 16 points and Derrick Walton added 14 for the Big Ten leaders. The Wolverines (16-4, 8-0) shot 61 percent from the field against a Purdue team that had held its previous five opponents under 42.
The Boilermakers (13-8, 3-5) were led by A.J. Hammons, who had 16 points and eight rebounds.
Michigan was coming off three straight wins over top-10 teams, and there was no letdown at home against Purdue.